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Commissioning and performance evaluation of the new electron UHDR FLASHKNiFE® system for FLASH radiation therapy
Julie Colnot1, Imane Said Mansour2, Cathyanne Schott2
1INSERM U1030, Université Paris-Saclay, Gustave Roussy, Villejuif, France; Radiotherapy department, Gustave Roussy, Villejuif, France; THERYQ, Rousset, France.
Objective:
This study aimed to evaluate and validate the new FLASHKNiFE ultra-high dose rate (UHDR) radiotherapy system by commissioning and assessing the dosimetric performance of its electron UHDR beams to ensure accuracy and stability.
Material And Methods:
The FLASHKNiFE system is a mobile linear accelerator delivering UHDR electron beams (>40 Gy/s, 6 and 10 MeV) at various pulse repetition frequencies (10-250 Hz) and pulse widths (0.5-4 μs). Its dose monitoring system includes two independent current transformers for precise dose measurements. Performance tests were adapted from AAPM reports, IEC standards, and recent recommendations, focusing on repeatability, output stability, PDD curves, cross profiles, dose linearity, and the influence of UHDR parameters on dose distribution. Dose-independent detectors, such as radiochromic films and the FlashDiamond, ensured measurement accuracy.
Results:
Long-term output reproducibility was better than 5 %, and energy stability was within 2.5 %. PDD curves remained consistent within 1 mm. Delivered dose was proportional to pulse number and PW within 2 %, except for the lowest settings. Cross profiles met IEC standards for flatness and symmetry. Maximum axis doses for a 10-cm applicator were 1.3 Gy/pulse (10 MeV) and 1.1 Gy/pulse (6 MeV) at PW = 2 μs, achieving dose rates over 275 Gy/s. Dosimeter results were consistent within uncertainties.
Conclusion:
The FLASHKNiFE system has been validated for preclinical studies, demonstrating robust, reproducible performance and providing a solid foundation for ongoing QA processes.
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