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Published on: November 28, 2015
IL-6: a pivotal molecule for tumor-brain dysfunction interaction
Yuan-Yuan Wang1, Yong-Fei Wang2, Wei-Lin Jin2
1Institute of Cancer Neuroscience, Medical Frontier Innovation Research Center, The First Hospital of Lanzhou University, The First Clinical Medical College of Lanzhou University, Lanzhou 730000, China; School of Life Science, Lanzhou University, Lanzhou 730000, China.
None:
Neuropsychiatric complications of cancer cachexia include apathy. Zhu et al. identified a brain circuit sensitive to tumor-driven interleukin-6 (IL-6) signaling that directly reduces motivation by suppressing dopaminergic activity. Targeted circuit-based and pharmacologic interventions, including systemic anti-IL-6 antibodies, reversed motivational deficits and point to new therapeutic avenues for apathy.
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