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Related Experiment Video

Updated: Jun 10, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

Changes in cognitive status after parathyroidectomy-a prospective panel study.

Milan Jovanovic1,2, Katarina Tausanovic3,4, Nikola Slijepcevic3,4

  • 1Clinic for Endocrine Surgery, University Clinical Center of Serbia, Belgrade, Serbia. milanjovanovicceh@gmail.com.

Updates in Surgery
|June 3, 2025
PubMed
Summary

Related Concept Videos

The Parathyroid Glands00:59

The Parathyroid Glands

The two pairs of parathyroid glands embedded within the posterior surface of the thyroid gland are restricted by a dense capsule around them. These glands comprise two distinct cell populations—parathyroid oxyphil and parathyroid principal cells- pivotal in calcium homeostasis.
Oxyphil cells, whose functions remain elusive, emerge during late puberty, adding a layer of complexity to the parathyroid gland's intricacies. In contrast, principal parathyroid cells undertake a vital role by producing...

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This summary is machine-generated.

Primary hyperparathyroidism surgery significantly improves cognitive function. Cognitive status in patients with primary hyperparathyroidism showed lasting improvement six months post-parathyroidectomy, with age and education being key factors.

Area of Science:

  • Endocrinology
  • Neurosurgery
  • Cognitive Science

Background:

  • Primary hyperparathyroidism (pHPT) is increasingly linked to non-classical symptoms, notably cognitive impairment.
  • The impact of parathyroidectomy on cognitive function in pHPT patients requires further investigation.
  • Understanding perioperative factors influencing cognitive status is crucial for patient management.

Purpose of the Study:

  • To evaluate cognitive status in primary hyperparathyroidism patients before and after parathyroidectomy.
  • To assess the long-term effects of parathyroidectomy on cognitive function.
  • To identify factors influencing cognitive changes during the perioperative period.

Main Methods:

  • A two-year panel study involving 94 patients with pHPT scheduled for parathyroidectomy.
Keywords:
CognitionMini-Mental State ExaminationParathyroidectomyPrimary hyperparathyroidism

Related Experiment Videos

Last Updated: Jun 10, 2026

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy
03:57

Generation of Hypoparathyroid Rats via Carbon-Nanoparticle-Assisted Parathyroidectomy

Published on: July 14, 2023

  • Cognitive status assessed using the Mini-Mental State Examination (MMSE) preoperatively, and at one and six months post-surgery.
  • Multivariable mixed-effect modeling used to analyze the impact of various factors on cognitive outcomes.

    • Main Results:

    • Significant improvement in MMSE scores was observed six months after parathyroidectomy (27.93 to 28.87, p < 0.001).
    • Preoperative cognitive impairment (MMSE ≤ 25) was present in 7.5% of patients, reducing to one patient post-surgery.
    • Age and lower education level were identified as independent predictors of cognitive status.

    Conclusions:

    • Parathyroidectomy leads to significant and sustained cognitive improvement in patients with primary hyperparathyroidism.
    • Cognitive benefits of parathyroidectomy persist up to six months post-surgery.
    • While age and education influence cognitive outcomes, other perioperative variables did not significantly affect cognitive status.