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Updated: Sep 19, 2025
Microbiota Analysis Using Two-step PCR and Next-generation 16S rRNA Gene Sequencing
Published on: October 15, 2019
[Research progress on the relationship between gut microbiota and childhood bronchial asthma]
Lei Yu1, Mao-Lan Wu1, Xiang-Rong Zheng1
1Children's Medical Center, Xiangya Hospital of Central South University, Changsha 410008, China.
Insights
The gut microbiome influences childhood asthma development. Modulating gut bacteria offers a promising new treatment strategy for pediatric asthma.
Area of Science:
- Pediatric Pulmonology
- Microbiome Research
- Immunology
Background:
- Childhood asthma affects millions globally, presenting a significant health burden.
- Emerging research highlights the gut microbiota's crucial role in asthma development.
- Understanding this link is vital for novel therapeutic strategies.
Purpose of the Study:
- To review current research on the gut microbiota and childhood asthma.
- To elucidate the composition, function, and host interactions of gut microbiota.
- To explore the impact of microbial dysbiosis on asthma pathogenesis.
Main Methods:
- Literature review of studies investigating gut microbiota in pediatric asthma.
- Analysis of microbial composition, function, and host-microbe interactions.
- Synthesis of evidence on the role of gut dysbiosis in asthma development.
Main Results:
- Gut microbiota composition and function are significantly altered in children with asthma.
- Specific microbial profiles are associated with asthma onset and severity.
- Changes in gut microbiota impact immune system development and airway inflammation.
Conclusions:
- The gut microbiota is a key factor in childhood asthma.
- Modulating the gut microbiota presents a potential novel therapeutic avenue for asthma.
- Further research is warranted to translate these findings into clinical practice.
Abstract:
Bronchial asthma (asthma) is a complex inflammatory airway disease affecting approximately 100 million children worldwide, imposing a heavy burden on society and families. Studies have shown that the gut microbiota plays a significant role in the occurrence and development of childhood asthma. This paper reviews the research progress on the relationship between gut microbiota and childhood asthma. By elucidating the composition, function, and relationship with the host of gut microbiota, the impact of changes in its composition and function on the development of asthma is revealed. Furthermore, the potential value and application prospects of modulating gut microbiota as a new strategy for asthma treatment are discussed, providing a theoretical reference for in-depth research on the relationship between gut microbiota and the onset of childhood asthma and the development of new therapeutic approaches.
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