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Kasper Vinken1, Saloni Sharma1, Margaret S Livingstone1

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Summary
This summary is machine-generated.

This study introduces a novel data-driven method to map brain function across species using naturalistic stimuli. It enables precise alignment of macaque and human brain regions, advancing comparative neuroscience research.

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Area of Science:

  • Comparative Neuroscience
  • Neuroimaging
  • Primate Brain Research

Background:

  • Neuroscience commonly uses macaque models to understand human brain function.
  • Identifying homologous brain regions across species and measurement types, especially in higher-order cortex, is challenging due to non-homologous anatomy and narrow hypotheses.

Purpose of the Study:

  • To develop and validate a data-driven approach for mapping functional correspondence between macaque and human brains.
  • To overcome limitations of traditional methods relying on predefined concepts and limited stimuli.

Main Methods:

  • Directly compared macaque electrophysiology with human functional Magnetic Resonance Imaging (fMRI) data.
  • Utilized responses to 700 natural scenes as stimuli, focusing on response pattern similarity for alignment.
  • Applied the method to the ventral face patch system as a test case.

Main Results:

  • Achieved fine-grained functional alignment between macaque and human brain regions based on natural scene response patterns.
  • The identified correspondence aligns with full-brain anatomical warping.
  • Results contradict previous findings limited by narrow functional hypotheses.

Conclusions:

  • Natural image-evoked response patterns offer a robust basis for cross-species functional alignment in neuroscience.
  • This approach supports scalable comparisons as large-scale primate recordings increase.
  • Resolves ambiguities in cross-species brain region mapping, particularly in visual processing areas.