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Related Concept Videos

Understanding Sleep01:11

Understanding Sleep

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Sleep, an essential biological state, involves significant reductions in physical activity, sensory awareness, and interaction with the environment. This complex physiological process is primarily regulated by specific brain regions, notably the hypothalamus and pons, which govern the sleep-wake cycle or circadian rhythm.
The circadian rhythm, a nearly 24-hour cycle, is deeply influenced by environmental light cues. Light exposure directly affects the hypothalamus, which in turn regulates...
223

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An open, fully-processed data resource for studying mood and sleep variability in the developing brain.

Juliette B H Brook1,2,3, Taylor Salo1,2,3, Audrey C Luo1,2,3

  • 1Department of Psychiatry, University of Pennsylvania, Philadelphia, PA.

Biorxiv : the Preprint Server for Biology
|June 4, 2025
PubMed
Summary
This summary is machine-generated.

This study introduces an open neuroimaging dataset linking brain development, emotion regulation, and sleep patterns in young people. The resource supports research into mood, sleep, and adolescent brain changes.

Keywords:
ASLEMAactigraphyadolescenceaffective instabilitydMRIdevelopmentemotion regulationfMRIsleep

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Area of Science:

  • Neuroscience
  • Developmental Psychology
  • Sleep Science

Background:

  • Adolescence and early adulthood are critical periods for brain development, coinciding with significant changes in emotion regulation and sleep patterns.
  • Existing research often lacks integrated datasets that simultaneously capture affective dynamics, sleep variations, and multimodal brain development measures.
  • Understanding these interconnections is crucial for addressing mental health challenges during these formative years.

Purpose of the Study:

  • To introduce and describe the protocol for an open data resource that combines neuroimaging with detailed behavioral measures in adolescents and young adults.
  • To facilitate research on the complex interplay between mood, sleep, and neurodevelopmental trajectories during a critical life stage.
  • To provide a continuously updated, openly accessible dataset for the scientific community.

Main Methods:

  • Multi-echo functional MRI, compressed-sensing diffusion MRI, and advanced arterial spin-labeled MRI were employed to capture brain structure and function.
  • Densely sampled behavioral data were collected using ecological momentary assessment, actigraphy, cognitive assessments, and clinical phenotyping.
  • The initial release includes data from 10 participants, with ongoing accrual planned.

Main Results:

  • The study successfully established a protocol for collecting multimodal neuroimaging and behavioral data in adolescents and young adults.
  • An initial dataset (n=10) comprising raw and processed data is now openly available without restrictive data use agreements.
  • The resource is designed for regular updates as participant accrual continues.

Conclusions:

  • This open data resource offers a unique opportunity to investigate the relationships between emotion regulation, sleep, and brain development.
  • By providing comprehensive, multimodal data, it aims to accelerate scientific discovery in developmental neuroscience and mental health.
  • The open-access nature of the data promotes reproducibility and collaborative research efforts worldwide.