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Molecular Mechanisms and Therapeutic Targeting of Heat Shock Proteins (HSPs) in Cardiovascular Disorders

Jyoti Upadhyay1, Mukesh Nandave2, Kamal Y Thajudeen3

  • 1Department of Pharmaceutical Sciences, School of Health Science and Technology, UPES, Campus Bidholi Dehradun, 248007 Uttarakhand, India.

Frontiers in Bioscience (Landmark Edition)
|June 4, 2025
PubMed

Insights

Heat shock proteins (HSPs) are crucial biomarkers for predicting and diagnosing cardiovascular diseases. Understanding HSPs and their regulatory pathways offers new avenues for disease intervention and therapeutic management.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Cardiology

Background:

  • Heat shock proteins (HSPs) are vital molecular chaperones involved in protein stability and cellular homeostasis.
  • Aberrant HSP expression is linked to various diseases, necessitating a deeper understanding of their roles.

Purpose of the Study:

  • To comprehensively review the role of HSPs as predictive biomarkers in cardiovascular diseases.
  • To explore the regulatory pathways governing HSP function in cardiovascular health and disease.

Main Methods:

  • Systematic literature review of original publications from 2010 to 2024.
  • Keywords used: "heat-shock proteins", "HSP in cardiovascular disorders", "HSP in atherosclerosis".

Main Results:

  • HSPs are critical regulators of apoptosis, protein folding, immune responses, genomic stability, and DNA repair.
  • Dysregulation of HSPs contributes to the development and progression of cardiovascular diseases.

Conclusions:

  • HSPs serve as versatile biomarkers for cardiovascular diseases, aiding in prediction and diagnosis.
  • Targeting HSPs presents a promising strategy for the therapeutic management of cardiovascular conditions.

Keywords:
atherosclerosiscardiovascular diseasesheat shock proteinpredictive biomarker

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