Related Experiment Video

Updated: Sep 19, 2025

Yeast As a Chassis for Developing Functional Assays to Study Human P53
14:57

Yeast As a Chassis for Developing Functional Assays to Study Human P53

Published on: August 4, 2019

9.7K

CircTP53/USP10/p53 signaling Axis as a Novel Regulator of Progression and Prognosis of Head and Neck Squamous Cell

Yin Wang1,2, Fen Chang1,2, Zinan Li1,2

  • 1Department of Otorhinolaryngology, Qilu Hospital of Shandong University, Jinan, Shandong, China.

Advanced Science (Weinheim, Baden-Wurttemberg, Germany)
|June 4, 2025
PubMed

Insights

A novel TP53-derived circRNA (circTP53) is upregulated in head and neck squamous cell carcinoma (HNSCC). This circRNA promotes tumor progression by stabilizing p53 via the USP10 interaction, offering potential new therapeutic targets.

Area of Science:

  • Oncology
  • Molecular Biology
  • Genetics

Background:

  • Precision therapy for head and neck squamous cell carcinoma (HNSCC) lacks effective biomarkers.
  • TP53 is frequently mutated in HNSCC, but its derived circRNAs and regulatory roles in HNSCC are largely unexplored.

Purpose of the Study:

  • To identify and characterize novel TP53-derived circRNAs in HNSCC.
  • To elucidate the mechanism of circTP53 in HNSCC progression and its potential as a therapeutic target.

Main Methods:

  • Identification of circTP53 using RNA sequencing.
  • In vitro and in vivo experiments to assess circTP53's role in HNSCC progression.
  • Co-immunoprecipitation and interaction analysis to determine circTP53-USP10-p53 axis.

Main Results:

  • circTP53 is upregulated in HNSCC and associated with poor prognosis.
  • circTP53 promotes HNSCC progression both in vitro and in vivo.
  • circTP53 stabilizes p53 by interacting with USP10, enhancing its deubiquitinating activity.
  • circTP53 exhibits opposing effects on cell viability and tumor growth depending on p53 mutation status.

Conclusions:

  • circTP53 is a novel oncogenic circRNA in HNSCC.
  • The circTP53/USP10/p53 axis represents a potential therapeutic strategy for HNSCC precision medicine.
Keywords:
DeubiquitinationHNSCCUSP10circTP53p53

More Related Videos

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma08:59

A Model for Perineural Invasion in Head and Neck Squamous Cell Carcinoma

Published on: January 5, 2017

10.8K
Development of Compendium for Esophageal Squamous Cell Carcinoma03:36

Development of Compendium for Esophageal Squamous Cell Carcinoma

Published on: April 12, 2024

534

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
4.6K
Interactions Between Signaling Pathways01:19

Interactions Between Signaling Pathways

Signaling cascades usually lack linearity. Multiple pathways interact and regulate one another, allowing cells to integrate and respond to diverse environmental stimuli.
Convergence and divergence, and cross-talk between signaling pathways
Two distinct signaling pathways can converge on a single functional unit, which may either be a single protein or a complex of proteins. The response is either functionally distinct or synergistic between the two pathways but different from the response...
6.6K
Negative Regulator Molecules01:23

Negative Regulator Molecules

Positive regulators allow a cell to advance through cell cycle checkpoints. Negative regulators have an equally important role as they terminate a cell’s progression through the cell cycle—or pause it—until the cell meets specific criteria.
36.2K
mTOR Signaling and Cancer Progression03:03

mTOR Signaling and Cancer Progression

The mammalian target of rapamycin or mTOR protein was discovered in 1994 due to its direct interaction with rapamycin. The protein gets its name from a yeast homolog called TOR. The mTOR protein complex in mammalian cells plays a major role in balancing anabolic processes such as the synthesis of proteins, lipids, and nucleotides and catabolic processes, such as autophagy in response to environmental cues, such as availability of nutrients and growth factors.
The mTOR pathway or the...
3.9K
Tumor Progression02:07

Tumor Progression

Tumor progression is a phenomenon where the pre-formed tumor acquires successive mutations to become clinically more aggressive and malignant. In the 1950s, Foulds first described the stepwise progression of cancer cells through successive stages.
Colon cancer is one of the best-documented examples of tumor progression. Early mutation in the APC gene in colon cells causes a small growth on the colon wall called a polyp. With time, this polyp grows into a benign, pre-cancerous tumor. Further...
6.5K
Cancer-Critical Genes II: Tumor Suppressor Genes01:05

Cancer-Critical Genes II: Tumor Suppressor Genes

Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
When the function of certain critical genes, especially those involved in cell cycle regulation and cell growth signaling cascades, gets disrupted, it upsets the cell cycle progression. Such cells with unchecked cell cycles start proliferating uncontrollably and eventually develop into tumors.
Such genes that act...
8.2K