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Visual Detection of Multiple Nucleic Acids in a Capillary Array
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Dynamic Liposome Sensing Platform to Wirelessly Ensure Nucleic Acid Encapsulation via Non-Contact Perception.

Younsu Jung1, Jinhwa Park1,2, Seonghun Shin3

  • 1Department of Biophysics, Institute of Quantum Biophysics, Research Engineering Center for R2R Printed Flexible Computer, Sungkyunkwan University, Suwon-si, 16419, Rep. of Korea.

Small (Weinheim an Der Bergstrasse, Germany)
|June 4, 2025
PubMed
Summary
This summary is machine-generated.

A new dynamic liposome sensing platform uses electret-coated thin film transistors to monitor nucleic acid-loaded liposomes. This noncontact system achieves high encapsulation efficiency, crucial for gene therapeutics and mRNA vaccines.

Keywords:
droplet microfluidicslabel‐freeliposomeroll‐to‐rollthin‐film transistor

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Area of Science:

  • Biomedical Engineering
  • Nanotechnology
  • Materials Science

Background:

  • High-throughput, noncontact monitoring of nucleic acid payload in liposomes is essential for advancing gene therapeutics.
  • Current methods may lack efficiency or require direct contact, limiting scalability.

Purpose of the Study:

  • To develop a novel dynamic liposome sensing (DLs) platform for efficient, noncontact monitoring of DNA-loaded liposomes.
  • To leverage bio-inspired designs for improved sensitivity and throughput in liposome analysis.

Main Methods:

  • Implementation of an electret layer (CYTOP)-coated single-walled carbon nanotube-based thin film transistor (eSWCNT-TFT).
  • Roll-to-roll (R2R) printing of SWCNT-TFTs on plastic film, integrated with a droplet microfluidic chip.
  • Monitoring of electrostatic potential differences induced by liposomes to determine net-charge variations.

Main Results:

  • The DLs platform detected DNA-loaded liposomes by measuring shifts in threshold voltage (Vth) without direct contact.
  • Achieved a maximum encapsulation efficiency of 87.3 ± 3.2% with a sensitivity of 18.61 nA ppm⁻¹ per droplet.
  • Demonstrated scalability for in-situ checks of messenger ribonucleic acid (mRNA)-based vaccines.

Conclusions:

  • The developed eSWCNT-TFT based DLs platform offers a high-throughput, noncontact solution for monitoring nucleic acid payload in liposomes.
  • This technology has significant potential for quality control in gene therapy and vaccine production, particularly for mRNA-based products.