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Updated: Sep 19, 2025

A Customizable Approach for the Enzymatic Production and Purification of Diterpenoid Natural Products
Published on: October 4, 2019
Leucophyllusins A-H: new abietane, pimarane, and ent-kaurane diterpenoids from Isodon leucophyllus
Si-Ying Tian1, Kun Hu2, Han-Dong Sun2
1State Key Laboratory of Phytochemistry and Natural Medicines, Kunming Institute of Botany, Chinese Academy of Sciences, Kunming 650201, People's Republic of China; University of Chinese Academy of Sciences, Beijing 100049, People's Republic of China.
Abstract:
Eight new diterpenoids, leucophyllusins A-H (1-8), along with 19 known analogues (9-27) were obtained from the aerial parts of Isodon leucophyllus. Among them, abietanoids represented the predominant structural class. The structures and absolute configurations of all new compounds were unambiguously determined through a comprehensive analytical approach combining 1D/2D NMR, HRESIMS, and quantum chemical calculations. All compounds were tested for their inhibitory activity against arachidonic acid-induced platelet aggregation and lipopolysaccharide-stimulated nitric oxide production in RAW264.7 macrophage cells. However, none exhibited significant activity relative to the positive controls.
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