Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Microvessel diameter changes during hemorrhagic shock in unanesthetized hamsters.

A Colantuoni, S Bertuglia, M Intaglietta

    Microvascular Research
    |September 1, 1985
    PubMed
    Summary

    Hypovolemic shock causes arterial vessels to lose vasomotion and contract, except for terminal arterioles which dilate. Venous vessels show varied responses, with small veins contracting during shock.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Emergent behaviors in RBCs flows in micro-channels using digital particle image velocimetry.

    Microvascular research·2017
    Same author

    Further evidence of a prolonged hypotensive and a bradycardic effect after mandibular extension in normal volunteers.

    Archives italiennes de biologie·2017
    Same author

    Microvascular Blood Flow Improvement in Hyperglycemic Obese Adult Patients by Hypocaloric Diet.

    Translational medicine @ UniSa·2016
    Same author

    Red blood cells flows in rectilinear microfluidic chip.

    Annual International Conference of the IEEE Engineering in Medicine and Biology Society. IEEE Engineering in Medicine and Biology Society. Annual International Conference·2016
    Same author

    Control of overweight and obesity in childhood through education in meal time habits. The 'good manners for a healthy future' programme.

    Pediatric obesity·2015
    Same author

    Lower weight loss expectations and healthier eating attitudes in older overweight and obese women attempting weight loss.

    Clinical obesity·2015

    Area of Science:

    • Physiology
    • Microcirculation Research
    • Hemorrhage Studies

    Background:

    • The microvasculature exhibits vasomotion, rhythmic diameter changes, in normal physiological conditions.
    • Hypovolemic shock, induced by blood loss, significantly impacts circulatory dynamics.
    • Understanding microvascular responses to shock is crucial for managing circulatory collapse.

    Purpose of the Study:

    • To investigate the effects of hypovolemic shock on the diameter and vasomotion of small arteries and arterioles.
    • To characterize the differential responses of various microvessel types to hemorrhage.
    • To observe the recovery of microvascular function after reinfusion.

    Main Methods:

    • Utilized the hamster skin fold window preparation for in vivo microvascular visualization.

    Related Experiment Videos

  • Induced hypovolemic shock by withdrawing blood to a mean arterial blood pressure of 40 mm Hg.
  • Monitored and measured diameter changes and vasomotion in arterioles and venules before, during, and after shock and reinfusion.

    • Main Results:

    • Arterial vessels (A1-A3) lost vasomotion and contracted significantly during shock.
    • Terminal arterioles (A4) showed initial dilation and loss of vasomotion.
    • Small veins (V1) contracted, while other venules (V2-V4) exhibited no significant diameter changes.
    • Reinfusion restored vasomotion and microvascular patterns.

    Conclusions:

    • Microcirculatory responses to hypovolemic shock are heterogeneous and vessel-type dependent.
    • Differential reactivity of microvessels to hemorrhage mechanisms underlies these inhomogeneous responses.
    • The hamster skin fold window model effectively demonstrates dynamic microvascular changes during shock and recovery.