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Updated: Jun 14, 2025

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Atroposelective Suzuki-Miyaura Coupling Reaction with Benzoxaboroles
Yu-Qi Cui1, Peng Ye1, Ya-Ling Zhang1
1Catalytic Hydrogenation Research Center, State Key Laboratory of Green Chemical Synthesis and Conversion, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
None:
The asymmetric ring-opening Suzuki-Miyaura cross-coupling (SMC) reaction of ortho-disubstituted aryl bromides with cyclic benzoxaboroles has been developed for the first time by using a commercially available Et-AntPhos as the chiral ligand, offering general access to diverse axial chiral biaryl benzyl alcohols in high enantioselectivity (up to 97:3 er). This protocol also features mild reaction conditions and a broad substrate scope, demonstrating the potential of benzoxaboroles in asymmetric transformations.
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