Related Experiment Video

Updated: Jun 9, 2026

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies
09:29

Development and Maintenance of a Preclinical Patient Derived Tumor Xenograft Model for the Investigation of Novel Anti-Cancer Therapies

Published on: September 30, 2016

Revisiting galectin-1, -3, -4, and -9 as biotargets for colorectal cancer

Ammar Akram Kamarudin1,2, Nadiah Abu2

  • 1School of Biology, Faculty of Applied Sciences, Universiti Teknologi MARA (UiTM), Cawangan Negeri Sembilan, Kampus Kuala Pilah, 72000 Kuala Pilah, Negeri Sembilan, Malaysia.

Biochemistry and Cell Biology = Biochimie Et Biologie Cellulaire
|June 5, 2025
PubMed

Insights

This review summarizes the roles of specific galectins (galectin-1, -3, -4, and -9) in colorectal cancer development and their clinical trial involvement.

Area of Science:

  • Molecular Biology
  • Oncology
  • Biochemistry

Background:

  • Galectins are proteins with a conserved carbohydrate recognition domain involved in cellular functions.
  • They play diverse roles in different tissues and are implicated in various diseases, including cancer.
  • Specific galectins, notably galectin-1, -3, -4, and -9, are studied for their involvement in colorectal cancer.

Purpose of the Study:

  • To review the specific roles of galectins in colorectal cancer.
  • To highlight the involvement of galectins in ongoing clinical trials for colorectal cancer.

Main Methods:

  • Literature review of studies on galectins in colorectal cancer.
  • Analysis of galectin involvement in clinical trials.

Main Results:

  • Galectins exhibit distinct functions and varying roles in different tissues.
  • Galectin-1, -3, -4, and -9 have been particularly implicated in colorectal cancer progression.
  • These galectins are subjects of investigation in clinical trials for colorectal cancer treatment.

Conclusions:

  • Galectins are significant players in colorectal cancer pathogenesis.
  • Understanding galectin functions is crucial for developing novel therapeutic strategies.
  • Clinical trials are exploring galectin-targeted therapies for colorectal cancer.
Keywords:
biomarkersbiotargetscolon cancergalectin-9galectinsrectal cancer

More Related Videos

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments10:59

Glycomics-Guided Glycoproteomics Facilitates Comprehensive Profiling of the Glycoproteome in Complex Tumor Microenvironments

Published on: February 7, 2025

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine06:24

Establishment of Coloproctitis Cancer Model in Mice and Evaluation of Therapeutic Effect of Chinese Medicine

Published on: October 13, 2023

Related Concept Videos

Targeted Cancer Therapies02:57

Targeted Cancer Therapies

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against specific...
Selectins01:25

Selectins

Cell adhesion is  an essential aspect of multicellularity. While stable cell interactions usually occur between cells of the same type, transient cell interactions occur between cells of different tissue types, such as between neutrophils and endothelial cells. Selectins are one class of cell adhesion molecules (CAMs) that bind carbohydrate ligands to form transient cell adhesion. They are rod-like proteins with a long extracellular part of variable length ending with the lectin domain, which...