Related Experiment Video
Updated: Sep 19, 2025

Optogenetic Entrainment of Hippocampal Theta Oscillations in Behaving Mice
Published on: June 29, 2018
Neuroglia's signaling: orchestrating neuronal gamma synchrony?
Mie Andersen1, Hajime Hirase1,2, Celia Kjaerby1
1Center for Translational Neuromedicine, University of Copenhagen, Copenhagen, Denmark.
Purpose Of Review:
Gamma oscillations (30-80 Hz) play a crucial role in sensory processing and cognitive functions, with disruptions in these rhythms linked to neurological disorders such as schizophrenia and Alzheimer's disease. This review highlights the emerging role of astrocytes in regulating gamma oscillations, emphasizing their contribution to the inhibitory tone and extracellular ion homeostasis.
Recent Findings:
Recent studies suggest that astrocytes facilitate gamma synchrony, while dysfunction in astrocytic activity - such as impaired Ca 2+ signaling - is associated with deficits in gamma oscillations and increased network hyperexcitability. Thus, astrocytic dysfunction may contribute to the pathophysiology of gamma-related disorders.
Summary:
By examining the role of astrocytes in maintaining neuronal network stability, this review highlights new aspects of neuroglia signaling.
Related Concept Videos
Neuronal Communication
Nervous Tissue: Glial Cells
The CNS glial cell includes the astrocytes, the oligodendrocytes, the microglia, and the ependymal cells.
Astrocytes are star-shaped glial...
Glial Cells
Neurons as Communicators of the Brain
Cell Body
The cell body, also known...
Synaptic Signaling
Neurogenesis and Regeneration of Nervous Tissue

