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Updated: May 27, 2026
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Published on: May 2, 2025
Experimental Study on New Polymer Dressings to Accelerate the Epithelialization in Wound Healing
Cafer Yildirim1, Nuray Bayar Muluk2, Mustafa Yazir3
1Basic Medical Sciences, Faculty of Dentistry, Ankara University, Ankara, Turkey.
Objectives:
In this study, the authors applied polymers to an open wound and tried to determine their contribution to its closure or healing process.
Methods:
Eighteen adult male Wistar albino rats weighing between 190 and 220 g were used in the experiment. The animals were randomly divided into groups (n=6): group 1, group 2, and group 3. First experimental group (polymer 1, IY-04-109 ) (n=6), second experimental group (polymer 2, IY-04-225) (n=6), third control group (meloline) (n=6). Wounds with a diameter of 0.3cm were created in the dorsal region of the animals; the polymer patches provided were fixed to the wound from both sides with 2 simple sutures.
Results:
IY-04-109 and IY-04-225 are similar in composition and synthesis. They should both be biocompatible. Both are polydimethyl silicon-urea copolymers. The differences are that IY-04-109 used a PDMS with a molecular weight of 3200 g/mol, and urea was 13.9%. It was determined that polymer suturing upon the wound surface provided healing with healthy mucosa before scar tissue developed. Both groups, 1 and 2, were better than the control group. Polymer IY-04-225, used in group 2 animals, accelerated the epithelialization faster.
Conclusion:
In IY-04-225, a PDMS with a molecular weight of 11,000 g/mol was used. The amount of urea is 9.6%. There is more PDMS in IY-04-225, and the molecular weight of the PDMS is very high. This can lead to differences in polymer surface properties, which may explain why the second group is slightly better.
