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Two Earlier Undescribed Flavanone Glycosides From the Leaves of Croton dongnaiensis With Their Acetylcholinesterase
Nguyen Thi Kim Thuy1, Nguyen Duc Duy1, Nguyen Thi Hanh1
1High-Tech Research and Development Center, Vietnam Academy of Science and Technology, Cau Giay, Hanoi, Vietnam.
Abstract:
Two undescribed flavanol glycosides (1 and 2), together with 10 known phenolic compounds (3-12) were isolated from the leaves of Croton dongnaiensis. Their chemical structures were determined by high-resolution electrospray ionization mass spectrometry and nuclear magnetic resonance spectra. The absolute configuration of compounds 1 and 2 were elucidated by electronic circular dichroism spectra. Compounds 1-12 showed weak acetylcholinesterase inhibitory activity with IC50 values ranging from 72.31 ± 2.14 to 251.24 ± 6.18 µM.
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