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Published on: December 19, 2017
Tellurium nanowire retinal nanoprosthesis improves vision in models of blindness
Shuiyuan Wang1,2, Chengyong Jiang1, Yiye Yu3
1State Key Laboratory of Integrated Chips and Systems (SKLICS), College of Integrated Circuits and Micro-Nano Electronics, School of Microelectronics, State Key Laboratory of Brain Function and Disorders, MOE Frontiers Center for Brain Science, Institutes of Brain Science, Department of Ophthalmology and Vision Science, Eye and ENT Hospital, Fudan University, Shanghai, China.
Abstract:
Present vision restoration technologies have substantial constraints that limit their application in the clinical setting. In this work, we fabricated a subretinal nanoprosthesis using tellurium nanowire networks (TeNWNs) that converts light of both the visible and near-infrared-II spectra into electrical signals. The broad-spectrum coverage is made possible by a combination of narrow bandgaps, strong absorption, and engineered asymmetries. Implanted into blind mice, the TeNWNs restored pupillary reflexes and enabled visually cued learning under visible and near-infrared 1550-nanometer light. In nonhuman primates, TeNWNs elicited robust retina-derived neural responses, confirming biocompatibility and feasibility. By restoring lost photosensitivity and extending vision to near-infrared, this nanoprosthesis offers a promising approach for restoring vision.
