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Hyperchloraemia: a non-specific finding in chronic renal failure.

G Enia, C Catalano, C Zoccali

    Nephron
    |January 1, 1985
    PubMed
    Summary

    Hyperchloraemia, or high plasma chloride, is common in chronic renal failure (CRF), affecting 30-50% of patients. This condition is linked to increased acidosis in individuals with impaired kidney function.

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    Area of Science:

    • Nephrology
    • Clinical Chemistry

    Background:

    • Chronic renal failure (CRF) is characterized by impaired kidney function.
    • Electrolyte imbalances, including hyperchloraemia, are potential complications of CRF.

    Purpose of the Study:

    • To investigate the prevalence of hyperchloraemia in patients with chronic renal failure.
    • To explore the association between hyperchloraemia and acidosis in CRF patients.

    Main Methods:

    • Retrospective analysis of acid-base and electrolyte status.
    • Inclusion of 102 Italian and 53 English patients with impaired renal function.

    Main Results:

    • Hyperchloraemia (plasma chloride ≥ 107 mmol/l) was prevalent across all stages of CRF (30-50%).
    • Prevalence was notable in tubulointerstitial nephropathies (45%) and chronic glomerulonephritis (39%).

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  • Hyperchloraemic patients exhibited greater acidosis compared to normochloraemic patients.

    • Conclusions:

    • Hyperchloraemia is a frequent finding in chronic renal failure.
    • The presence of hyperchloraemia correlates with increased acidosis in CRF.
    • Monitoring chloride levels is important in managing patients with chronic kidney disease.