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Updated: May 5, 2026

Measuring Volatile and Non-volatile Antifungal Activity of Biocontrol Products
Published on: December 5, 2020
Trichodermanols A-C, three new metabolites from the Ganoderma lucidum-derived endophytic Trichoderma sp. GLQ02 and
Ping-Ping Wu1, Xin-Huan Qiu2, Hua-Jin Yu2
1School of Pharmaceutical Sciences, Guangxi University of Chinese Medicine, Nanning 530200, China.
Abstract:
Trichodermanols A-C (1-3), an uncommon nor-steroid (1) and two novel 5/7 ring system sesquiterpenes (2 and 3), along with two known compounds identified as (1S,7R,10S,11R)-3-oxoguai-4-ene-11,12-diol (4) and cyclo-((S)-Pro-(R)-Leu) (5), were isolated and elucidated from a Ganoderma lucidum-derived endophytic fungus Trichoderma sp. GLQ02. Their chemical structures were elucidated on the basis of spectroscopic data and ECD and DP4+ calculations. The biological activity of new isolates 1-3 was evaluated in LPS-stimulated RAW 264.7 cells. The results revealed that trichodermanol A (1) exhibited potential anti-inflammatory activity.

