Advances in Lung Cancer Basic and Translational Research in 2025 - Overview and Perspectives Focusing on NSCLC

Area of Science:

• Basic and translational science in thoracic oncology.
• Molecular mechanisms of lung cancer development and progression.

Background:

• Lung cancer research is rapidly advancing, improving early detection, diagnosis, and treatment personalization.
• Recent breakthroughs have deepened the understanding of lung cancer's molecular genomics, proteomics, pathogenesis, and cellular biology.

Purpose of the Study:

• To highlight current research in non-small cell lung cancer (NSCLC).
• To focus on molecular risk factors and key biological processes in lung cancer.
• To identify future research directions for improved patient survival and curative therapies.

Main Methods:

• Review of current basic and translational research in lung cancer.
• Focus on molecular risk factors, tumorigenesis, heterogeneity, phenotypic plasticity, metabolic reprogramming, immunobiology, immune microenvironment, and microbiome.
• Synthesis of findings by the IASLC Basic and Translational Science (BaTS) Committee.

Main Results:

• Comprehensive overview of NSCLC research areas.
• Emphasis on the complex interplay of molecular, cellular, and environmental factors in lung cancer.
• Identification of critical areas for future investigation.

Conclusions:

• Continued basic and translational research is crucial for advancing lung cancer care.
• Future research focusing on identified areas holds promise for improved survival and curative treatments, particularly for advanced disease.
• The IASLC BaTS Committee aims to guide future scientific leadership in thoracic cancer research.