Related Experiment Video
Updated: Jun 12, 2025
Visualizing and Quantifying Pharmaceutical Compounds within Skin using Coherent Raman Scattering Imaging
Published on: November 24, 2021
Advances in transdermal delivery systems for Antifungals: Current approaches and future perspectives
Rania Hamed1, Ahlam Zaid Alkilani2, Yasmeen Al-Adhami1
1Department of Pharmacy, Faculty of Pharmacy, Al-Zaytoonah University of Jordan, Jordan, Amman, 11733, Jordan.
Abstract:
Fungal infections, which affect approximately one billion people worldwide, pose significant health challenges due to their unique eukaryotic cell structures, requiring specialized treatments. Common fungal infections, such as dermatophyte-related conditions, vary from superficial to severe. Their prevalence is increasing due to factors like immunosuppression and acquired immunodeficiency syndrome (AIDS). While topical treatments are the primary approach, they often encounter limitations such as poor skin penetration. Additionally, conventional formulations require high doses and frequent administration. Recent advancements, including novel carriers, aim to overcome these challenges and reduce local side effects. This review highlights the innovations in transdermal drug delivery systems for antifungal agents, focusing on azoles, polyenes, echinocandins, allylamines, and other antifungal agents. Innovative delivery technologies, such as liposomes, microneedles, and microemulsions, are underscored to enhance skin permeation, improve drug stability, and ensure sustained release. The review emphasizes the improved efficacy and antifungal activity of these systems compared to traditional methods. It also addresses their safety and clinical potential, offering new strategies to improve treatment outcomes for fungal skin infections.
Insights
Novel transdermal drug delivery systems enhance antifungal treatments for widespread fungal infections. These innovative methods improve drug penetration and efficacy, offering better outcomes for skin fungal infections.
Area of Science:
- Mycology
- Dermatology
- Pharmaceutics
Background:
- Fungal infections affect one billion people globally, presenting treatment challenges due to eukaryotic cell structures.
- Increasing prevalence is linked to factors like immunosuppression and acquired immunodeficiency syndrome (AIDS).
- Conventional topical antifungal treatments face limitations like poor skin penetration and frequent administration.
Purpose of the Study:
- To review innovations in transdermal drug delivery systems for antifungal agents.
- To highlight technologies enhancing skin permeation, drug stability, and sustained release.
- To assess the improved efficacy, safety, and clinical potential of novel delivery systems.
Main Methods:
- Review of current literature on transdermal drug delivery systems for antifungal agents.
- Focus on innovative carriers including liposomes, microneedles, and microemulsions.
- Analysis of antifungal agents such as azoles, polyenes, echinocandins, and allylamines.
Main Results:
- Innovative delivery technologies significantly enhance skin permeation and antifungal activity.
- Novel carriers improve drug stability and enable sustained release compared to conventional methods.
- These advanced systems demonstrate improved efficacy and reduced local side effects.
Conclusions:
- Transdermal drug delivery systems offer promising strategies to overcome limitations of traditional antifungal treatments.
- Innovations in delivery technologies can improve treatment outcomes for superficial and severe fungal skin infections.
- Further research into the safety and clinical potential of these systems is warranted.
More Related Videos
08:54Broth Microdilution In Vitro Screening: An Easy and Fast Method to Detect New Antifungal Compounds
Published on: February 14, 2018
09:06Author Spotlight: Photodynamic Therapy as a Novel Approach to Induce Petite Colonies in Drug-Resistant Candida for Antifungal Research
Published on: March 29, 2024
Related Concept Videos
01:16Drug Delivery: Overview
Enteral delivery involves administering drugs directly through swallowing, sublingual placement, or buccal application. Orally administered drugs predominantly navigate the...
01:22Drug Delivery: Miscellaneous Routes
Oral inhalation and nasal sprays swiftly transfer drugs across the respiratory epithelium's mucosal layer. Inhaled glucocorticoids and bronchodilators directly target lung conditions such as asthma, while fluticasone nasal spray mitigates allergic rhinitis.
Transdermal patches transport drugs...
01:15Non-Oral Extravascular Drug Absorption Routes
Lipophilic drugs that are stable at salivary pH (6) and exhibit minimal binding to the oral mucosa are absorbed more...
01:18Drug Delivery: Enteral Route
01:17Pore Transport and Ion-Pair Transport
Pore transport, also known as convective transport, is a process where small molecules like urea, water, and sugars rapidly cross cell membranes as though there were channels or pores in the membrane. Although direct microscopic evidence is limited but the concept of pores or channels is widely accepted based on physiological evidence. Despite the lack of direct...
01:22Routes of Drug Administration: Overview
Enteral administration refers to drugs absorbed through the gastrointestinal tract. They can be swallowed (perorally), placed under the tongue (sublingually), or on the inner lining of the cheeks (buccally). Perorally administered drugs take time to be absorbed and have a slower onset of action. The rectal route is another form of enteral administration, which allows for...