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Measurement of Basal and Forskolin-stimulated Lipolysis in Inguinal Adipose Fat Pads

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Cryolipolysis for Submental Fat Reduction: A Systematic Review and Meta-Analysis.

Kenny Do¹, Nabih Ghani¹, Nathan Lloyd¹

¹Department of Otolaryngology - Head and Neck Surgery, Kirk Kerkorian School of Medicine at UNLV, Las Vegas, Nevada.

Facial Plastic Surgery : FPS

|June 5, 2025

Summary

This summary is machine-generated.

Cryolipolysis effectively reduces submental fat, a common cosmetic concern. This noninvasive treatment offers significant fat reduction with minimal side effects, improving patient appearance.

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Area of Science:

Aesthetics
Dermatology
Medical Technology

Background:

Submental fat is a prevalent aesthetic concern addressed by surgical and nonsurgical methods.
Cryolipolysis is a noninvasive technique utilizing cold temperatures to induce adipose tissue apoptosis.
Evaluating cryolipolysis for submental fat reduction is crucial for understanding its clinical utility.

Purpose of the Study:

To systematically review and meta-analyze the efficacy and safety of cryolipolysis for submental fat reduction.
To quantify changes in submental fat thickness and volume post-treatment.
To assess the overall effectiveness and tolerability of cryolipolysis in this specific application.

Main Methods:

Systematic review and meta-analysis adhering to PRISMA guidelines.
Comprehensive literature search across major databases (PubMed, Scopus, Web of Science).
Inclusion of eight pre-post studies with 206 patients meeting specific criteria.

Main Results:

Pooled analysis revealed a significant mean reduction in submental fat thickness of -2.78 mm.
A substantial mean reduction in submental fat volume of -19.57 cm³ was observed.
Cryolipolysis demonstrated a favorable safety profile with transient, minimal side effects.

Conclusions:

Cryolipolysis is a safe and effective noninvasive treatment for reducing submental fat.
The procedure leads to statistically significant and clinically relevant reductions in fat volume and thickness.
This meta-analysis supports cryolipolysis as a viable option for patients seeking submental fat reduction.