Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Cystic Fibrosis: Pathogenesis01:23

Cystic Fibrosis: Pathogenesis

370
Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...
370
The JAK-STAT Signaling Pathway01:20

The JAK-STAT Signaling Pathway

9.3K
Several cytokine receptors have tightly bound Janus kinase or JAK proteins attached at their cytosolic tail. Small signaling molecules such as cytokines, growth hormones, or prolactins bind to the cytokine receptors and initiate their dimerization. The dimerization brings the cytosolic JAKs together that trans-phosphorylate and activates each other. The activated JAKs now phosphorylate cytosolic tails of the cytokine receptors, which serve as binding sites for adaptor proteins such as  SH2...
9.3K
Pulmonary Hypertension: Classification and Pathogenesis01:30

Pulmonary Hypertension: Classification and Pathogenesis

300
Pulmonary hypertension (PH) is a severe health condition in which the mean pulmonary arterial pressure increases to 25 mmHg or more, even when the body is at rest. This high pressure in the blood vessels that transport blood from the heart to the lungs can cause various symptoms, including shortness of breath, can lead to right heart failure, and significantly affect the overall quality of life.
There are various classifications for PH, each relating to different underlying causes and also...
300
Major Somatic Sensory Pathways01:28

Major Somatic Sensory Pathways

1.3K
Sensory impulses related to touch, pressure, vibration, and proprioception from various body parts, such as the limbs, trunk, neck, and posterior head, travel to the cerebral cortex through the posterior column-medial lemniscus pathway. The pathway’s name derives from the two white-matter tracts that convey the impulses: the spinal cord's posterior column and the brainstem's medial lemniscus. First-order sensory neurons extend their axons into the spinal cord, forming the...
1.3K
Pneumonia II: Pathophysiology01:29

Pneumonia II: Pathophysiology

622
The pathophysiology of pneumonia involves the following steps:
622
Urinary Tract Infection II: Pathophysiology01:25

Urinary Tract Infection II: Pathophysiology

54
The pathophysiology of urinary tract infections (UTIs) encompasses several progressive stages, beginning with bacterial colonization and culminating in potential systemic complications if untreated. UTIs are primarily initiated by bacteria, such as Escherichia coli, which often originate from the gastrointestinal tract and migrate to the urinary system through the periurethral area. This migration can occur via several routes, including improper hygiene practices, sexual activity, or...
54

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Multiple Antibiotic Allergy Evaluation Strategy (MAAES): A Comparative Effectiveness Study.

The journal of allergy and clinical immunology. In practice·2026
Same author

Prospective longitudinal study of psychological sequelae, self-perception of body image, and quality of life in severe cutaneous adverse drug reactions: a case-control study.

Frontiers in medicine·2026
Same author

Comprehensive mapping of human CD4<sup>+</sup> T cell epitopes for Nipah and measles as prototype Paramyxoviruses.

Cell reports. Medicine·2026
Same author

Isotopic Fractionation and Masking Effects during Biotransformation of Chlorinated Ethanes.

Environmental science & technology·2026
Same author

Decoding the human CD4<sup>+</sup> T cell epitope repertoire for Lassa fever virus reveals T cell-based pan-mammarenavirus vaccine candidates.

Cell reports. Medicine·2026
Same author

Cutaneous and histopathological features of drug reaction with eosinophila and systemic symptoms differ by HIV status in an HIV-endemic setting.

JAAD international·2026

Related Experiment Video

Updated: Sep 19, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

545

Updates in the pathogenesis of SJS/TEN.

Joy Justice1, Eric Mukherjee2, Michelle Martin-Pozo3

  • 1Vanderbilt University School of Medicine, Nashville, TN, USA.

Allergology International : Official Journal of the Japanese Society of Allergology
|June 5, 2025
PubMed
Summary

Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe drug reactions. New research explores T-cell activation, genetic links, and targeted treatments to improve outcomes for these life-threatening conditions.

Keywords:
CytotoxicHLA antigensStevens-Johnson syndromeT-lymphocytesToxic epidermal necrolysis

More Related Videos

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
09:25

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

Published on: August 19, 2016

11.1K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from S&#233;zary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

5.6K

Related Experiment Videos

Last Updated: Sep 19, 2025

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma
10:21

Author Spotlight: Exploring the Role of Inflammation in the Co-occurrence of Primary Sjogren's Syndrome and Lung Adenocarcinoma

Published on: September 20, 2024

545
Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells
09:25

Implementation of a Permeable Membrane Insert-based Infection System to Study the Effects of Secreted Bacterial Toxins on Mammalian Host Cells

Published on: August 19, 2016

11.1K
Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from S&#233;zary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

5.6K

Area of Science:

  • Immunology
  • Dermatology
  • Pharmacology

Background:

  • Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis (TEN) are severe cutaneous adverse drug reactions.
  • These conditions involve widespread epidermal detachment and keratinocyte apoptosis, leading to significant morbidity and mortality.
  • Current treatment is limited to supportive care, highlighting the need for better therapeutic strategies.

Purpose of the Study:

  • To review recent advancements in understanding the immunopathogenesis of SJS/TEN.
  • To explore novel insights into T-cell activation, cell death pathways, and genetic associations.
  • To identify potential targeted treatment options for SJS/TEN.

Main Methods:

  • Review of current literature on SJS/TEN pathogenesis.
  • Analysis of recent research on immune mechanisms, including T-cell responses and apoptotic/necroptotic mediators.
  • Examination of genetic associations and potential therapeutic targets.

Main Results:

  • SJS/TEN pathogenesis involves complex immunologic responses, strongly HLA class I restricted.
  • Recent research elucidates mechanisms of T-cell activation and mediators of keratinocyte apoptosis and necroptosis.
  • Genetic associations provide insights into disease susceptibility and potential diagnostic markers.

Conclusions:

  • A comprehensive understanding of SJS/TEN immunopathogenesis is crucial for developing effective treatments.
  • Targeted therapies based on elucidated mechanisms hold promise for reducing SJS/TEN morbidity and mortality.
  • Further research into genetic factors and immune pathways can guide prevention and diagnosis.