[Clostridioides difficile infection]

This clinical review examines the epidemiology, diagnosis and treatment of Clostridioides difficile infection, a feared cause of diarrhoea following use of antibiotics. A third of cases are diagnosed outside the hospital setting, and one in four patients experience a relapse despite seemingly successful treatment. Norwegian and international guidelines have recently updated their recommendations on antibiotic choices for primary infection. Doctors both in hospitals and outside the hospital setting should be familiar with risk factors, diagnostics and treatment principles.