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Updated: Sep 19, 2025

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Giant malignant phyllodes tumor: A case report
Daniela Kerguelen Murcia1, Andrea Tenreiro2, Jennifer A Kohlnhofer2
1John Sealy School of Medicine, University of Texas Medical Branch, Galveston, TX, USA.
Abstract:
Phyllodes tumor is a rare fibroepithelial breast mass that typically manifests as a painless, multinodular breast tumor. One characteristic feature of phyllodes tumors is that they tend to increase in size rapidly over time unlike fibroadenomas. On ultrasound, they typically appear as a hypoechoic solid mass that may contain cystic components. On mammography, they appear hyperdense. Definitive diagnosis requires biopsy, with histological findings of leaf-like architecture and stromal cellularity. This report presents a case of giant malignant phyllodes tumor in a 53-year-old female who underwent right mastectomy and provides an overview of its clinical presentation, diagnostic workup, radiologic imaging findings, and management.
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