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Schizophrenia patients show disrupted sense of agency, unlike healthy controls. This impairment is linked to hallucinations and delusions, not medication or cognitive deficits.

Keywords:
delusionhallucinationintentional bindingpassivitytemporal perception bias

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Area of Science:

  • Cognitive Neuroscience
  • Psychiatry
  • Clinical Psychology

Background:

  • Neurocognitive processes underlying the sense of agency are frequently disrupted in schizophrenia.
  • Previous studies have not fully controlled for confounding factors like temporal perception, medication, or executive functioning.

Purpose of the Study:

  • To investigate the sense of agency in schizophrenia patients while controlling for potential confounding variables.
  • To examine the relationship between agency disturbances, specific symptoms (delusions, hallucinations, passivity), and temporal perception biases.

Main Methods:

  • Utilized the intentional binding phenomenon, an implicit measure of agency, in 30 schizophrenia patients and 30 healthy controls.
  • Employed active (self-initiated action) and passive (externally controlled action) conditions to assess agency.
  • Administered comprehensive neuropsychological assessments and symptom evaluations, including positive, negative, and passivity symptoms.

Main Results:

  • Healthy controls exhibited the intentional binding effect, particularly with shorter action-outcome delays.
  • Schizophrenia patients demonstrated an absence of the intentional binding effect.
  • The observed alteration in agency was significantly moderated by temporal perception biases, hallucinations, and delusions.

Conclusions:

  • This study provides novel evidence linking disturbances in the sense of agency to symptomatology and temporal perception in schizophrenia, independent of medication effects.
  • Findings support a predictive coding model of the sense of agency and highlight the role of specific symptoms in agency deficits.