Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Shock lung and diffuse alveolar damage pathological and pathogenetic considerations.

J B Blennerhassett

    Pathology
    |April 1, 1985
    PubMed
    Summary
    This summary is machine-generated.

    Related Concept Videos

    You might also read

    Related Articles

    Articles linked to this work by shared authors, journal, and citation graph.

    Sort by
    Same author

    Clinical outcomes of the Otago-Southland Breast Cancer Screening Programme 1991-1996.

    The New Zealand medical journal·1998
    Same author

    Pseudo-lymphocyte monocytes--the memory cells responsible for the development of epitheloid cell granulomata. A new hypothesis.

    Pathology·1981
    Same author

    Muramidase content of cells in human granulomatous reactions.

    Pathology·1981
    Same author

    Experimental granulomatous inflammation: the ultrastructure of the reaction of guinea pigs to bentonite injection.

    The Journal of pathology·1980
    Same author

    Experimental granulomatous inflammation: the ultrastructure of the granuloma induced by injection of tubercle bacilli into Freund adjuvant-sensitised guinea-pigs.

    The Journal of pathology·1979
    Same author

    Experimental granulomatous inflammation: I. Gross and light microscopical observations in freund adjuvant-sensitized Cavies following the injection of killed tubercle bacilli.

    Pathology·1979
    Same journal

    Impact of the 2025 Endocrine Society clinical practice guideline on the diagnosis and management of primary aldosteronism for the clinical laboratory.

    Pathology·2026
    Same journal

    Cribriform intraductal carcinoma of the prostate may have a greater prognostic impact even than Gleason grade 5 conventional prostatic adenocarcinoma.

    Pathology·2026
    Same journal

    Bordetella pertussis: emerging epidemiology, diagnosis and management.

    Pathology·2026
    Same journal

    Development and validation of a real-time polymerase chain reaction for the detection of Haycocknema perplexum.

    Pathology·2026
    Same journal

    Recent advances in the understanding of TP53 in haematological malignancies.

    Pathology·2026
    Same journal

    Concurrent renal amyloid light chain amyloidosis, light chain crystalline podocytopathy and light chain proximal tubulopathy: a case report.

    Pathology·2026
    See all related articles

    Diffuse alveolar damage, a lung injury with diverse causes, presents a uniform pathology and pathogenesis. Management of acute respiratory distress syndrome focuses on supportive care due to high mortality.

    Area of Science:

    • Pulmonary Medicine
    • Pathology
    • Critical Care

    Background:

    • Diffuse alveolar damage (DAD) results from numerous injurious agents.
    • Etiology varies, but the lung pathology is consistently characterized by exudative and proliferative phases.
    • Clinically, DAD manifests as acute respiratory distress syndrome (ARDS) with high mortality.

    Purpose of the Study:

    • To elucidate the uniform pathology and pathogenesis of DAD despite diverse etiologies.
    • To highlight the common therapeutic strategies for ARDS.
    • To discuss the cellular mechanisms underlying DAD.

    Main Methods:

    • Review of existing literature on DAD and ARDS.
    • Pathological analysis of lung tissue in different phases of DAD.

    Related Experiment Videos

  • Discussion of pathogenetic mechanisms including cellular damage and inflammatory mediators.

    • Main Results:

    • DAD progresses through acute exudative and subacute proliferative phases.
    • Pathogenesis involves damage to endothelial cells and pneumocytes via direct action, free radicals, or leukotrienes.
    • In shock-associated DAD, complement activation and phagocyte-derived lysosomal enzymes play a key role.

    Conclusions:

    • Despite varied causes, DAD shares a common pathological pathway.
    • ARDS management necessitates uniform supportive therapeutic measures.
    • Understanding pathogenesis informs supportive care strategies for DAD.