Analysis of photothermal therapy effect on AuNPs injection depth based on diffusion behavior analysis using two...

Area of Science:

• Biomedical Engineering
• Oncology
• Nanotechnology

Background:

• Photothermal therapy (PTT) offers a non-invasive treatment for cancer, utilizing localized heating to eliminate tumor tissue.
• Gold nanoparticles (AuNPs) are effective photothermal agents, enabling targeted cancer cell destruction with minimal damage to surrounding healthy tissue.

Purpose of the Study:

• To numerically analyze the effectiveness of PTT for treating squamous cell carcinoma (SCC) in the skin.
• To optimize PTT parameters, including gold nanoparticle injection depth, elapsed time, and laser power, for enhanced therapeutic outcomes.

Main Methods:

• Simulated gold nanoparticle distribution and diffusion over time following injection at various depths relative to the SCC.
• Calculated temperature distribution within the tissue by varying laser power and elapsed time post-injection.
• Quantified thermal damage using two discrimination models, comparing tumor and normal tissue responses.

Main Results:

• Determined optimal gold nanoparticle injection depths ranging from 0.5 mm to 2.5 mm.
• Established effective treatment windows based on elapsed time (0-12 hours) and laser power (0-0.8 W).
• Demonstrated the potential for accurate thermal damage quantification and relative analysis between tumor and normal tissues.

Conclusions:

• Numerical analysis confirms the efficacy of PTT for skin SCC treatment.
• The study provides a framework for optimizing PTT parameters to improve treatment accuracy and minimize side effects.
• Findings support the development of more precise, non-invasive cancer therapies using nanotechnology.