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Updated: Sep 19, 2025

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Interstitial cervical needle-guide ring-cap prototype for patient-specific ring-and-tandem brachytherapy.

Larence T Kuete1, Alyssa Glennon2, Sarah Ptashnik3

  • 1Personalized Medicine and Applied Engineering, Yale University, New Haven, CT.

Brachytherapy
|June 6, 2025
PubMed
Summary

A novel 3D-printed guide cap enhances cervical brachytherapy by enabling patient-specific needle placement with improved radiation dose delivery for hybrid intracavitary-interstitial brachytherapy (IC/ISBT). This improves treatment precision and patient outcomes.

Keywords:
3D printingBrachytherapyBrachytherapy needle placementGynecological cancerHigh-dose-rate brachytherapyHybrid intracavitary interstitial brachytherapyInterstitial brachytherapyInterstitial needleRing and tandem applicator

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Area of Science:

  • Medical Physics
  • Oncology
  • Biomedical Engineering

Background:

  • Hybrid intracavitary-interstitial brachytherapy (IC/ISBT) is a crucial treatment for cervical cancer.
  • Existing applicators have limitations in achieving patient-specific interstitial needle placement.
  • Optimizing radiation dose distribution is key to improving treatment efficacy and reducing toxicity.

Purpose of the Study:

  • To develop and evaluate a novel 3D-printed guide cap for MRI-compatible ring-and-tandem (R&T) applicators.
  • To enable patient-specific interstitial needle guidance in hybrid IC/ISBT.
  • To assess the impact of the guide cap on radiation dosimetry for the target volume and organs at risk.

Main Methods:

  • A unique guide cap with six interstitial needle channels was designed using SolidWorks and 3D-printed.
  • The guide cap was tested for compatibility with a commercial R&T applicator and interstitial needles.
  • Dosimetric analysis was performed by replanning patient cases using virtual needle paths in EclipseBV software.

Main Results:

  • 3D-printed guide caps demonstrated physical compatibility with the R&T applicator.
  • Interstitial needles could be accommodated with a bending precision of ±1°.
  • Significant improvements in target volume coverage (HR-CTV D90%) and reductions in organ-at-risk doses (bladder, rectum, sigmoid, small bowel D2cc) were observed.

Conclusions:

  • A novel 3D-printed guide cap prototype enhances existing R&T applicators for IC/ISBT.
  • The guide cap facilitates patient-specific interstitial needle placement with customizable angles and positions.
  • This innovation improves radiation dosimetry, offering potential for more effective and safer cervical cancer treatment.