Nurr1 modulators - a patent review (2019-present)

Area of Science:

• Neuroscience
• Pharmacology
• Molecular Biology

Background:

• Nuclear receptor related 1 (Nurr1) is a transcription factor with neuroprotective and anti-neuroinflammatory properties.
• Nurr1 modulation is a potential therapeutic strategy for neurodegenerative diseases and cancers.
• Development of potent and selective Nurr1 modulators remains a challenge.

Purpose of the Study:

• To review recent advancements in the discovery of small molecule Nurr1 modulators.
• To analyze patent applications for novel Nurr1 ligands and their proposed applications.
• To assess the progress and limitations in Nurr1 ligand development.

Main Methods:

• Literature review of scientific publications and patent applications (01/2019-09/2024).
• Analysis of Nurr1 ligand scaffolds, including natural and synthetic derivatives.
• Evaluation of claimed therapeutic uses, focusing on neurodegenerative diseases and cancer.

Main Results:

• Recent patent applications reveal growing interest in small molecule Nurr1 modulators.
• Identified Nurr1 ligands are based on prostaglandin A, dihydroxyindole, and synthetic scaffolds.
• Proposed applications primarily target neurodegenerative conditions and cancer treatment.

Conclusions:

• Nurr1 modulation is an emerging therapeutic concept with significant progress in ligand discovery.
• Patent landscape shows promising compounds, but validation and specificity require further investigation.
• Broad claims in some patents necessitate rigorous experimental evidence for claimed efficacy.