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Primary open-angle glaucoma: a perspective from plasma metabolomics
Emily Dorairaj1,2, Alex Arshavsky1,3, Sanjoy K Bhattacharya1
1Miami Integrative Metabolomics Research Center, Bascom Palmer Eye Institute, Miller School of Medicine, University of Miami, Miami, FL, USA.
Expert Review of Molecular Diagnostics
|June 7, 2025
Summary
Metabolomic plasma biomarkers show promise for improving primary open-angle glaucoma (POAG) diagnosis and treatment. Further research is needed to standardize methods for earlier detection and personalized care.
Area of Science:
- Ophthalmology
- Metabolomics
- Biomarker Discovery
Background:
- Primary open-angle glaucoma (POAG) is a progressive optic neuropathy causing vision loss.
- Current diagnostic tools like OCT and perimetry have limitations in tracking disease progression.
- There is a need for advanced biomarkers to enhance POAG management.
Purpose of the Study:
- To review the current state of POAG management and identify limitations.
- To explore the potential of plasma-derived metabolomic biomarkers in POAG.
- To provide an overview of emerging biomarkers for POAG.
Main Methods:
- Literature review of POAG management strategies.
- Analysis of the current landscape of POAG plasma metabolomics.
- Identification of potential future biomarkers.
Main Results:
- Metabolomic biomarkers may improve early detection and personalized treatment for POAG.
- These biomarkers can complement existing diagnostic methods.
- Challenges include lack of standardization in protocols and outcome recording.
Conclusions:
- Advances in metabolomic biomarkers can significantly improve clinical outcomes in POAG.
- Standardization of protocols, diverse study populations, and longitudinal validation are crucial.
- Future research should focus on addressing these challenges for clinical implementation.
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