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Emulsifying and stabilizing ability of alkylated chitosan
Tatiana N Popyrina1, Nadejda A Aksenova2, Anastasia A Shilkova3
1Enikolopov Institute of Synthetic Polymeric Materials RAS, 70 Profsoyuznaya st., Moscow 117393, Russia; Moscow Aviation Institute (National Research University), 4 Volokolamskoe sh., Moscow 125993, Russia.
International Journal of Biological Macromolecules
|June 7, 2025
Summary
Alkylated chitosan demonstrates superior emulsifying and stabilizing properties compared to unmodified chitosan for creating emulsions and biodegradable microparticles. Higher concentrations of alkylated chitosan enhance emulsion stability and microparticle yield.
Area of Science:
- Materials Science
- Polymer Chemistry
- Colloid Science
Background:
- Chitosan is a biopolymer with potential applications in drug delivery and biomaterials.
- Modifying chitosan's chemical structure can enhance its functional properties.
- Understanding emulsification and stabilization mechanisms is crucial for microparticle fabrication.
Purpose of the Study:
- To compare the emulsifying and stabilizing abilities of alkylated chitosan versus unmodified chitosan.
- To evaluate the impact of chitosan modification on simple emulsions and polylactide microparticles.
- To investigate the relationship between chitosan solution characteristics and emulsion/microparticle properties.
Main Methods:
- Preparation of simple emulsions and polylactide microparticles using oil/water emulsion solvent evaporation.
- Characterization of emulsion properties: droplet size, size distribution, stability, emulsifying activity, and emulsification stability.
- Analysis of microparticle characteristics: yield, size, morphology, and surface composition.
- Evaluation of chitosan solution properties: viscosity, surface tension, and hydrophilic lipophilic balance (HLB).
Main Results:
- Alkylated chitosan exhibited enhanced emulsifying and stabilizing abilities compared to unmodified chitosan across tested concentrations (0.5-2 wt%).
- Higher concentrations of alkylated chitosan led to improved emulsion stability, smaller droplet sizes, increased viscosity, lower HLB, and reduced surface tension.
- Alkylated chitosan resulted in a higher total yield of biodegradable microparticles with a smaller mean size.
Conclusions:
- Alkylation significantly improves the emulsifying and stabilizing performance of chitosan.
- Alkylated chitosan is a more effective emulsifier for producing stable emulsions and high-quality biodegradable microparticles.
- The findings suggest alkylated chitosan as a promising material for advanced formulations and drug delivery systems.
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