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Laser-Driven microjet via metal foil ablation.

Ting-Ting Liu1, Xiao-Jie Zhang1, Kai Chen2

  • 1Hangzhou Dianzi University, Hangzhou, Zhejiang, China.

Lasers in Medical Science
|June 8, 2025
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Summary

This study presents a novel laser-driven microjet system for transdermal drug delivery. Aluminum foil, when ablated by a laser, generates microjets reaching 105 m/s, significantly improving drug delivery efficiency.

Keywords:
Finite element analysisLaser ablationMetal foilsMicrojetTransdermal delivery

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Area of Science:

  • Biomedical Engineering
  • Materials Science
  • Laser Physics

Background:

  • Transdermal drug delivery faces challenges in efficiency and penetration.
  • Laser-induced plasma and shock waves offer potential for novel propulsion methods.
  • Microjet technology can enhance targeted and controlled substance delivery.

Purpose of the Study:

  • To introduce and validate a novel laser-driven microjet system for transdermal drug delivery.
  • To investigate the material deformation characteristics of different metal foils under laser ablation.
  • To analyze the performance of generated microjets for efficient drug propulsion.

Main Methods:

  • Laser ablation of aluminum and copper foils adhered to a silicone membrane using a nanosecond Nd: YAG laser.
  • Real-time deformation measurement using displacement sensors and high-speed videography (1000 kfps).
  • Finite element analysis (ABAQUS) to simulate foil deformation and validate experimental results.

Main Results:

  • Aluminum foil exhibited 1.6-1.73 times greater deformation than copper foil under similar laser energy.
  • Increased laser energy led to higher deformation velocity and acceleration for both foils, particularly aluminum.
  • Generated microjets reached velocities up to 105 m/s, demonstrating efficient propulsion.

Conclusions:

  • The laser-driven microjet system using aluminum foil is a viable and efficient method for transdermal drug delivery.
  • Material properties and laser energy significantly influence microjet generation and performance.
  • This technology holds promise for enhanced drug delivery with significant theoretical and practical implications.