Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Chronic Obstructive Pulmonary Disease-III: Symptoms and Complications.

Understanding the variety of primary symptoms and systemic complications that characterize chronic obstructive pulmonary disease (COPD) is crucial for healthcare professionals.
Symptoms of COPD can be classified as primary or systemic. Primary symptoms relate to reduced airflow, while systemic or extrapulmonary symptoms relate to COPD's broader impact on the body.
Primary Symptoms of COPD:

COPD: Pathogenesis and Clinical Features

COPD: Pathogenesis and Clinical Features

Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Chronic Obstructive Pulmonary Disease-IV: Assessement and Diagnostic Studies

Assessing and diagnosing Chronic Obstructive Pulmonary Disease (COPD) involves a detailed approach that includes a comprehensive review of medical history, physical examination, and a variety of diagnostic tests. This thorough evaluation is essential to ensure an accurate diagnosis and guide effective management strategies.
Medical History

Pneumonia II: Pathophysiology

Pneumonia II: Pathophysiology

The pathophysiology of pneumonia involves the following steps:

Chronic Obstructive Pulmonary Disease

Chronic Obstructive Pulmonary Disease

COPD is defined as a heterogeneous lung condition marked by persistent respiratory symptoms such as dyspnea, cough, and sputum production, caused by abnormalities in the airways that cause airflow obstruction.
Smoking is a primary risk factor for COPD, with over 80% of patients having a history of it. Patients typically experience progressive dyspnea or labored breathing, frequent coughing, and recurrent pulmonary infections. Many eventually succumb to respiratory failure, characterized by...

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease-II: Pathophysiology

Chronic Obstructive Pulmonary Disease (COPD) pathophysiology is intricate and multifaceted, involving a complex interplay of physiological processes. Understanding these mechanisms is crucial for effectively managing and treating COPD. Here is an in-depth look at the critical elements in the pathophysiology of COPD:
Chronic Inflammation

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Acute mediastinitis, mediastinal granuloma, and fibrosing mediastinitis: a narrative review.

Mediastinum (Hong Kong, China)·2026

Same author

Insights From a National Inpatient Sample on the Epidemiologic Patterns of Cryptogenic Organizing Pneumonia: Signals, Not Certainties.

Chest·2026

Same author

A 38-Year-Old Woman With Sudden Dyspnea After Uterine Artery Embolization.

Chest·2026

Same author

Characteristics of patients with acute respiratory failure in obesity hypoventilation syndrome in the intensive care unit: A retrospective cohort study.

Respiratory medicine·2026

Same author

Docetaxel-Induced Serositis Mimicking Malignant Pleural Effusion.

Clinical case reports·2026

Same author

CT-Based Deep Foundation Model for Predicting Immune Checkpoint Inhibitor-Induced Pneumonitis Risk in Lung Cancer.

medRxiv : the preprint server for health sciences·2026

Search research articles

Related Experiment Video

Updated: Jun 12, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

A 65-year-old man with cough, hypercalcemia, and diffuse opacities.

Philip K Angelides¹, Oriana Salamo², Sujith V Cherian²

¹Department of Internal Medicine, Baylor College of Medicine, Houston, TX, USA.

Radiology Case Reports

|June 9, 2025

Summary

A low threshold for bronchoscopy is crucial for diagnosing opportunistic infections in cancer patients with pulmonary opacities. This case highlights histoplasmosis diagnosis via transbronchial biopsy, leading to improved outcomes.

Keywords:

Histoplasmosis Hypercalcemia Multiple myeloma Pulmonary nodules

More Related Videos

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Related Experiment Videos

Last Updated: Jun 12, 2025

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Lung CT Segmentation to Identify Consolidations and Ground Glass Areas for Quantitative Assesment of SARS-CoV Pneumonia

Published on: December 19, 2020

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Imaging Features of Systemic Sclerosis-Associated Interstitial Lung Disease

Published on: June 16, 2020

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Calcification of Vascular Smooth Muscle Cells and Imaging of Aortic Calcification and Inflammation

Published on: May 31, 2016

Area of Science:

Pulmonology
Infectious Diseases
Oncology

Background:

Respiratory infections are frequent in cancer patients, necessitating prompt diagnosis.
Opportunistic infections require a low threshold for bronchoscopy with bronchoalveolar lavage (BAL) in immunocompromised individuals with pulmonary findings.
Hypercalcemia in cancer patients usually indicates malignancy, but granulomatous diseases should be considered for persistent respiratory symptoms.

Observation:

A case of histoplasmosis presented with persistent pulmonary opacities and hypercalcemia in an immunocompromised patient.
Diagnosing histoplasmosis in immunocompromised patients can be challenging, with antigen testing and tissue biopsy/culture being key methods.

Findings:

Transbronchial biopsy was instrumental in diagnosing histoplasmosis in this patient.
Antigen testing may be more sensitive, but tissue biopsy or culture is often required for definitive diagnosis.

Implications:

Early and accurate diagnosis of opportunistic infections like histoplasmosis is vital for effective treatment in immunocompromised cancer patients.
Transbronchial biopsy can provide significant diagnostic value for unresolving respiratory symptoms and atypical infiltrates.
Considering granulomatous diseases is important in cancer patients with hypercalcemia and persistent respiratory issues.