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Updated: Jun 12, 2025

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Light-activated decellularized extracellular matrix-based bioinks for enhanced mechanical integrity.

Minji Kim1, Dayoon Kang1, Hohyeon Han2

  • 1Department of Mechanical Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37666, Republic of Korea.

Materials Today. Bio
|June 9, 2025
PubMed
Summary
This summary is machine-generated.

Photocrosslinking enhances decellularized extracellular matrix (dECM) bioinks for tissue engineering. These improved bioinks offer better mechanical properties and printability, advancing regenerative medicine applications.

Keywords:
3D bioprinting technologyBioinksDecellularized extracellular matrix (dECM)PhotocrosslinkingTissue engineering

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Area of Science:

  • Biomaterials Science
  • Tissue Engineering
  • Regenerative Medicine

Background:

  • Decellularized extracellular matrix (dECM)-based bioinks mimic native tissue environments.
  • dECM bioinks support crucial cellular functions for tissue analog development.
  • Current limitations include poor mechanical strength and printability.

Purpose of the Study:

  • To review advancements in light-mediated crosslinking of dECM bioinks.
  • To address challenges hindering translational utility of dECM bioinks.
  • To explore innovations in bioink design and crosslinking strategies.

Main Methods:

  • Examination of photocrosslinking technologies (methacrylates, thiol-enes, phenols).
  • Analysis of innovations in bioink formulation and photoinitiator design.
  • Review of optimized crosslinking kinetics and processing protocols.

Main Results:

  • Photocrosslinking significantly improves dECM bioink gelation, mechanical properties, and spatial fidelity.
  • Innovations address cytotoxicity and structural variability concerns.
  • Advancements enable higher resolution and volumetric tissue construct fabrication.

Conclusions:

  • Light-mediated crosslinking is crucial for overcoming dECM bioink limitations.
  • Standardized protocols and scalable techniques are necessary for clinical translation.
  • Enhanced dECM bioinks hold promise for transformative biomedical applications.