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Mechanistic Insights on Skin ageing and Dermatologic Interventions to Slow Ageing Process
1From the Department of Pharmacognosy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry, India.
Indian Journal of Dermatology
|June 9, 2025
Summary
Skin aging results from intrinsic and extrinsic factors, causing wrinkles and sagging. This review explores skin aging mechanisms and treatments, including procedures and energy-based devices.
Area of Science:
- Dermatology and Gerontology
- Molecular Biology and Biochemistry
Background:
- Skin aging is influenced by intrinsic (chronological) and extrinsic (environmental) factors.
- These factors induce morphological and physiological changes, leading to visible signs like wrinkles and sagging.
- Key molecular similarities in skin aging include reactive oxygen species and matrix metalloproteinases induction.
Purpose of the Study:
- To elucidate the mechanisms underlying skin aging.
- To review current management strategies for dermatologic aging.
- To discuss emerging trends in invasive procedures and energy-based devices for skin aging.
Main Methods:
- Literature review focusing on skin aging.
- Analysis of intrinsic and extrinsic aging factors.
- Examination of molecular pathways involved in skin aging.
- Review of therapeutic interventions for skin aging phenotypes.
Main Results:
- Intrinsic and extrinsic factors synergistically drive skin aging.
- Common aging phenotypes include coarseness, wrinkling, hyperpigmentation, telangiectasia, and sagging.
- Reactive oxygen species and matrix metalloproteinases are key molecular mediators.
- Various treatments, including invasive procedures and energy-based devices, are employed to address aging signs.
Conclusions:
- Understanding skin aging mechanisms is crucial for effective management.
- A combination of intrinsic and extrinsic factors contributes to skin aging.
- Current and emerging treatments aim to mitigate the visible effects of skin aging.
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