Modified probiotics and the related combinatorial therapeutics

Area of Science:

• Microbiology and Biotechnology
• Therapeutic Delivery Systems

Background:

• Probiotics show promise for disease prevention and treatment.
• In vivo challenges like harsh environments reduce probiotic viability and efficacy.
• Modified probiotics offer enhanced survival and therapeutic outcomes.

Purpose of the Study:

• To review physicochemical and biological modification strategies for probiotics.
• To explore advancements in probiotic-based combination therapies.
• To highlight new applications in disease treatment, bioimaging, and diagnosis.

Main Methods:

• Literature review of probiotic modification techniques.
• Analysis of research on combined probiotic therapies.
• Synthesis of findings on enhanced delivery and therapeutic effects.

Main Results:

• Modification strategies improve probiotic resistance and introduce beneficial characteristics.
• Combination therapies enhance the delivery of probiotics and active compounds.
• Modified probiotics show potential for improved disease treatment and diagnostics.

Conclusions:

• Probiotic modification is crucial for overcoming in vivo limitations.
• Combination therapies represent a promising strategy for advanced probiotic applications.
• Further research into modified probiotics can revolutionize disease management.