ARC Expands the DAAM1 Microexon-Mediated Actin-RHOA/ROCK Interplay
Patryk Poliński1, Marta Miret Cuesta2,3, Manuel Irimia2,3,4
1European Molecular Biology Laboratory, EMBL Barcelona, Barcelona, Spain.
None:
Actin cytoskeleton and its dynamics play a crucial role in synaptic function, influencing dendritic spines' structural and functional plasticity. Recent findings unveiled the significance of alternative splicing of a neural-specific microexon in DAAM1 in modulating actin's role in synaptic processes. This article discusses the impact of this microexon on actin polymerization, the RHOA/ROCK signaling pathway, and cognitive functions. Furthermore, we present new results that reveal a more complex scenario involving the upregulation of the activity-regulated cytoskeleton-associated protein (ARC) protein in DAAM1 microexon KO models, which may further affect synaptic function and cognition.
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