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Published on: April 23, 2012
Scabrosteroids A-D, Four Pyrrolidinone-Ergosterol Heterodimers from Penicillium scabrosum FXI744
Zheng Li1, Chun-Lun Qin1, Ting Zhou1
1School of Pharmacy, Tongji Medical College, Hubei Key Laboratory of Natural Medicinal Chemistry and Resource Evaluation, Huazhong University of Science and Technology, Wuhan 430030, P. R. China.
Abstract:
Scabrosteroids A-D (1-4), four novel steroidal heterodimers, were isolated from Penicillium scabrosum FXI744. These compounds represent the first naturally occurring pyrrolidinone-ergosterol hybrids, linked by a C-3/C-3' bond between pyrrolidinone and ergosterol moieties. Their structural elucidation, including the determination of absolute configurations, was accomplished using HRESIMS, NMR, X-ray crystallography, and ECD calculation. A plausible biosynthetic pathway for these metabolites was proposed. Biological evaluation revealed that compounds 1-4 inhibited NO production with IC50 values ranging from 9.5 to 14.4 μM, and compounds 1 and 4 also showed moderate in vitro immunosuppressive effects.
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Fungal Group Zygomycota
Fungal Phylum Microsporidia

