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This study introduces a robust nanoplatform using hydrogen-bonded organic frameworks (HOFs) for targeted cancer drug delivery. The Dox@nano-HOF 1 system effectively releases doxorubicin (Dox) at tumor sites, enhancing therapeutic efficacy and minimizing damage to healthy tissues.

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Area of Science:

  • Materials Science
  • Nanotechnology
  • Chemical Engineering

Background:

  • Hydrogen-bonded organic frameworks (HOFs) are promising porous materials for drug delivery due to their biocompatibility and porosity.
  • Challenges with HOFs include stability and controlled drug release, limiting their therapeutic applications.
  • Targeted drug delivery systems are crucial for improving cancer chemotherapy efficacy and reducing side effects.

Purpose of the Study:

  • To develop a stable and pH-responsive nanocarrier for targeted intracellular delivery of chemotherapeutics.
  • To investigate the potential of a novel HOF-based nanoplatform for delivering doxorubicin (Dox).
  • To evaluate the efficacy of the nanocarrier in cancer cells.

Main Methods:

  • Density functional theory (DFT) calculations were used to predict interactions between HOF components and doxorubicin.
  • A robust nanoplatform, Dox@nano-HOF 1, was synthesized.
  • In vitro studies including cytotoxic and apoptosis assays were performed to assess drug delivery efficacy.

Main Results:

  • DFT calculations confirmed strong noncovalent interactions suitable for drug encapsulation.
  • The Dox@nano-HOF 1 nanoplatform demonstrated pH-responsive release of doxorubicin at acidic pH.
  • Cytotoxic assays showed dose-dependent cancer cell death, confirming the nanocarrier's efficacy.

Conclusions:

  • Robust and reticular HOFs can be engineered for effective, pH-responsive drug delivery.
  • The Dox@nano-HOF 1 nanocarrier shows significant potential for targeted anticancer therapy.
  • This work expands the application of HOFs in advanced drug delivery systems.