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The Effect of Aging on Tissues01:19

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Several body functions deteriorate with age. The external signs of aging are easily identifiable. For example, the skin becomes dry, less elastic, and thins out, forming wrinkles. The skin of the face begins to appear looser due to a decrease in the levels of elastic and collagen fibers in the connective tissue. Additionally, melanin production in the hair follicle decreases with age, resulting in gray hair. Moreover, the senses of sight and hearing decline, so glasses and hearing aids may...
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Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
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Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
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It is convenient to consider the body's structures in terms of fundamental levels of organization that increase in complexity: subatomic particles, atoms, molecules, organelles, cells, tissues, organs, organ systems, and organisms.
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Updated: Sep 19, 2025

Isolation of Intermediate Filament Proteins from Multiple Mouse Tissues to Study Aging-associated Post-translational Modifications
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Contextualizing molecular and structural aging across human organs.

Juan Shu1,2, Yuxin Guo3, Julio Chirinos4,5

  • 1Department of Statistics and Data Science, University of Pennsylvania, Philadelphia, PA 19104, USA.

Medrxiv : the Preprint Server for Health Sciences
|June 10, 2025
PubMed
Summary
This summary is machine-generated.

This study reveals how organ-specific aging clocks, using protein and imaging data, capture different aspects of biological aging. These clocks offer new insights into age-related diseases and their underlying mechanisms.

Keywords:
Biological agingMagnetic resonance imagingMolecular and structural biologyNetwork biologyPlasma proteinsUK Biobank

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Area of Science:

  • Gerontology
  • Biomarkers
  • Multi-omics

Background:

  • Organ-specific aging clocks predict disease risk but their biological underpinnings are unclear.
  • Understanding molecular and structural aging mechanisms is crucial for aging research.

Purpose of the Study:

  • To investigate relationships between organ-specific and modality-specific aging clocks.
  • To uncover the biological processes and pathways reflected by these aging clocks.
  • To explore links between aging clocks, diseases, and lifestyle factors.

Main Methods:

  • Estimated paired protein-based and imaging-based aging clocks across 8 organs.
  • Analyzed proteomic and imaging data for phenotypic and genetic signatures.
  • Investigated enrichment of biological pathways (e.g., KEGG Alzheimer's disease pathway).

Main Results:

  • Protein and imaging aging clocks show distinct signatures and complementary roles in aging.
  • Multi-organ aging clocks converge to capture biological and disease pathways.
  • Identified modality-specific links between aging clocks, complex diseases, and lifestyle factors.

Conclusions:

  • A pan-organ, multi-modal approach is vital for understanding aging mechanisms and disease risk.
  • Aging clocks provide context-specific insights into aging biology and disease implications.
  • Intricate relationships among molecular and structural aging clocks revealed.