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Comparative Proteomic Analysis of Whole Kidney, Medulla, and Cortical Tubules in Diabetic Pathogenesis of Kidney Injury in Mice
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Cholesterol and Cardiovascular Risk in Type 2 Diabetes: The Role of Kidney Function
Ji-Hyun Kim1, Seung-Hwan Lee1, Kyu Na Lee2
1Division of Endocrinology and Metabolism, Department of Internal Medicine, Seoul St. Mary's Hospital, College of Medicine, The Catholic University of Korea, Seoul, Korea.
Journal of Lipid and Atherosclerosis
|June 10, 2025
Summary
Kidney function significantly impacts cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) patients. Lower kidney function amplifies CVD risk, even with controlled low-density lipoprotein cholesterol (LDL-C) levels, highlighting the need for tailored management strategies.
Area of Science:
- Cardiology
- Nephrology
- Endocrinology
Background:
- The interplay between lipid parameters, kidney function, and cardiovascular disease (CVD) risk in type 2 diabetes mellitus (T2DM) requires further investigation.
- Understanding these associations is crucial for optimizing CVD prevention strategies in T2DM patients.
Purpose of the Study:
- To evaluate the association between lipid parameters and CVD risk in T2DM patients.
- To determine the impact of varying levels of kidney function on this association.
Main Methods:
- A large cohort of 2,343,882 T2DM patients was analyzed using Korean National Health Insurance Service data (2015-2020).
- Patients were stratified by estimated glomerular filtration rate (eGFR) into three groups: ≥60, 30-59, and <30 mL/min/1.73 m2.
- Low-density lipoprotein cholesterol (LDL-C) levels and CVD incidence were assessed across eGFR strata.
Main Results:
- In patients with eGFR ≥60 mL/min/1.73 m2, CVD risk increased at LDL-C ≥100 mg/dL.
- In the eGFR 30-59 mL/min/1.73 m2 group, CVD risk was elevated by 43% even with LDL-C <70 mg/dL, and increased progressively with higher LDL-C.
- Patients with eGFR <30 mL/min/1.73 m2 faced a 3.3-fold increased CVD risk, even at LDL-C <70 mg/dL.
Conclusions:
- The threshold for LDL-C to increase CVD risk in T2DM patients is influenced by kidney function.
- Kidney function plays a significant role in modulating the relationship between LDL-C and CVD risk in T2DM.
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