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Updated: Jan 18, 2026

A Microwave-Assisted Direct Heteroarylation of Ketones Using Transition Metal Catalysis
Published on: February 16, 2020
HFIP-Assisted Relay Proton Transfer Facilitates Conjugate Addition of Amines to Vinyl Heteroarenes
Arijit Mahana1, Renuka Pradhan1, Manas Kumar Sahu1
1School of Chemical Sciences, National Institute of Science Education and Research (NISER), An OCC of Homi Bhabha National Institute, Bhubaneswar, 752050, India.
Abstract:
The Michael addition reaction of diverse acyclic and cyclic secondary amines towards 2-vinyl pyridine and vinyl quinoline was explored, using HFIP as the optimal potent solvent. Using this protocol, drug molecules with hypotensive and antivertigo properties were successfully synthesized, and ciprofloxacin was amenable in the reaction offering a pathway for drug modification. DFT studies reveal the role of HFIP during the solvent-assisted relay proton transfer step, leading to high product yields.
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