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Updated: Sep 19, 2025
The Colon-26 Carcinoma Tumor-bearing Mouse as a Model for the Study of Cancer Cachexia
Published on: November 30, 2016
Promising preclinical approaches to combating cancer-associated cachexia/tissue wasting
Savannah A Epstein1,2,3, Aneesha Dasgupta1,2,3, Jason D Doles1,2,3
1Department of Anatomy, Cell Biology and Physiology, Indiana University School of Medicine, Indianapolis, Indiana, USA.
Purpose Of Review:
To highlight promising pre-clinical work seeking to target cancer-associated tissue/muscle wasting.
Recent Findings:
This narrative review explores recent innovations and emerging/understudied aspects of cancer cachexia biology, highlighting representative studies across three key areas: (a) novel strategies for targeting established wasting pathways, (b) multimodal/combinatorial therapeutic approaches, and (c) mechanisms involving inter-tissue communication.
Summary:
Though not exhaustive, this review highlights three key areas of pre-clinical research with the potential to inform and inspire future clinical trials aimed at mitigating cachexia and tissue wasting in cancer patients.
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