[Treatment of Severe Lamotrigine Intoxication with Extracorporeal Therapy]

Lamotrigine is a drug that was initially used as an anticonvulsant and later its use was extended to mood disorders such as severe depression and bipolar disorder, being a safe drug with few adverse effects. Lamotrigine poisoning can present with mild symptoms such as palpitations and headache to more severe symptoms such as seizures, compromised consciousness, coma and cardiogenic shock. There is no described antidote for the treatment of this intoxication, so management is supportive; however, given the pharmacokinetic nature of the drug, extracorporeal therapies may be an option for severe cases. We present a case of severe lamotrigine poisoning managed with daily hemodialysis with a good clinical response.