Exploratory Advanced Radiotherapies for Ameloblastoma and Ameloblastic Carcinoma-A Concise Review

Area of Science:

• Oral and Maxillofacial Surgery
• Radiation Oncology
• Oncology

Background:

• Ameloblastoma is a challenging odontogenic tumor known for aggressive growth and high recurrence rates.
• Surgical resection is the primary treatment, but adjuvant therapies are considered for inoperable cases.

Purpose of the Study:

• To review case reports on advanced radiation therapy modalities for ameloblastoma.
• To assess treatment outcomes, including tumor response, side effects, and recurrence.

Main Methods:

• Systematic search of PubMed, Google Scholar, Embase, Web of Science, and Scopus.
• Inclusion of studies on helical tomotherapy, gamma knife radiosurgery, proton beam therapy, and carbon ion therapy for ameloblastoma.
• Evaluation of patient outcomes based on tumor response, radiation side effects, and recurrence.

Main Results:

• 78% of cases demonstrated tumor regression or complete response with no disease progression.
• Two cases showed partial regression or stable disease.
• Most side effects were mild (grade 1-3 dermatitis, mucositis, xerostomia), with two cases experiencing severe toxicity.

Conclusions:

• Advanced radiation techniques present a promising alternative or adjuvant therapy for ameloblastoma when surgery is contraindicated.
• Further research is necessary to validate these findings and establish definitive treatment protocols.