Related Experiment Video
Updated: Jun 12, 2025

An Efficient Sieving Method to Isolate Intact Glomeruli from Adult Rat Kidney
Published on: November 1, 2018
Developing a model renal corpuscle to illustrate concepts in renal physiology
Jacob E Hansen1, Jonathan A Chickering1, Amy J Sullivan1
1Department of Biology and Biochemistry, University of Northwestern-St. Paul, Roseville, Minnesota, United States.
This study introduces a simple model renal corpuscle (MRC) to teach kidney physiology. The model demonstrates how blood pressure and arteriole changes impact glomerular filtration for students.
Area of Science:
- Physiology
- Educational Models
Background:
- Lack of accessible models for renal fluid dynamics in education.
- Need for hands-on tools to teach renal physiology principles.
Purpose of the Study:
- To develop a rudimentary model renal corpuscle (MRC).
- To create an educational tool for teaching renal physiology to secondary and undergraduate students.
Main Methods:
- Construction of a basic MRC using readily available materials.
- Simulation of systemic blood pressure changes.
- Modulation of afferent arteriole diameter.
Main Results:
- The model allows users to observe the effects of simulated physiological changes on glomerular filtration.
- Demonstrates the relationship between systemic blood pressure, afferent arteriole, and filtration rate.
Conclusions:
- The developed MRC shows potential as an effective educational tool for renal physiology.
- Further modifications are recommended for optimizing the model for student use.
More Related Videos
09:00Microdissection of Primary Renal Tissue Segments and Incorporation with Novel Scaffold-free Construct Technology
Published on: March 27, 2018
09:43Epithelial Cell Repopulation and Preparation of Rodent Extracellular Matrix Scaffolds for Renal Tissue Development
Published on: August 10, 2015
Related Concept Videos
Renal Corpuscle
Glomerulus: Structure and Function
The glomerulus is a tiny, intricate network of capillaries located at the beginning of the nephron. It's enveloped by the Bowman's capsule and receives its blood supply from an afferent arteriole, which divides into numerous...
Nephrons
Internal Anatomy of the Kidney
Anatomical Position and Dimensions
The kidneys are retroperitoneal organs positioned against the posterior abdominal wall on either side of the spine, roughly between the twelfth thoracic and third lumbar vertebrae. Each kidney is typically 10-12 cm long, 5-6 cm wide, and 3-4 cm thick, weighing about 150 grams.
Renal Cortex
The outermost region of the kidney is the...
Kidney Structure
Renal Tubule and Collecting Duct
Proximal Convoluted Tubule (PCT):
The PCT is the initial segment of the renal tubule, extending from the Bowman's capsule that encloses the glomerulus. Its convoluted structure and microvilli-lined cells increase the surface area for reabsorption. The PCT reabsorbs glucose, amino acids, sodium, and water from the filtrate, ensuring essential...
Physiology of the Genitourinary System I: Renal Blood Flow and Glomerular Filtration