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Related Concept Videos

CNS Stimulants: Psychedelic Agents01:22

CNS Stimulants: Psychedelic Agents

127
Hallucinogens, also known as psychedelic drugs, are a class of substances known for their ability to alter perception, cognition, and emotions. Despite their profound effects on the mind, these drugs are non-addictive, setting them apart from many other abused substances. The mechanism of action of these drugs lies in their impact on the 5-HT2A receptor in the brain. Upon activation, this receptor couples to Gq-type G proteins, triggering a cascade that releases intracellular calcium. This...
127
Hallucinogens and Psychedelics01:27

Hallucinogens and Psychedelics

157
Hallucinogens are psychoactive substances that profoundly alter perceptual experiences, generating unreal visual and sensory images. Often referred to as psychedelic drugs — a term derived from the Greek words "psyche" (mind) and "delos" (revealing) — these substances include marijuana and lysergic acid diethylamide (LSD), among others. These drugs vary in intensity and effects.
Marijuana, derived from the dried leaves and flowers of the hemp plant, contains...
157

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Sexual Crosses with the Mucoromycete Phycomyces blakesleeanus
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Psychedelic fungi.

Jason Slot1, Dirk Hoffmeister2

  • 1Department of Plant Pathology, The Ohio State University, Columbus, OH 43210, USA.

Current Biology : CB
|June 10, 2025
PubMed
Summary
This summary is machine-generated.

Psychedelic fungi produce psychoactive compounds like psilocybin that affect brain receptors. Their biosynthesis and distribution across species are influenced by horizontal gene transfer, presenting new scientific opportunities.

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Area of Science:

  • Mycology
  • Neuroscience
  • Biochemistry

Background:

  • Psychedelic fungi produce diverse psychoactive compounds, including psilocybin, ibotenic acid, muscimol, and lysergic acid amides.
  • These compounds interact with human brain neurotransmitter receptors, causing significant psychological effects.
  • Psychoactive substances are found in various fungal groups, such as Psilocybe, Amanita, Claviceps, and Massospora.

Purpose of the Study:

  • To explore the diversity of psychedelic compounds produced by fungi.
  • To understand the ecological roles and biosynthesis of these fungal-derived psychoactive substances.
  • To examine the evolutionary mechanisms, like horizontal gene transfer, influencing the distribution of these compounds.

Main Methods:

  • Literature review and synthesis of existing research on fungal psychedelics.
  • Analysis of fungal genera known to produce psychoactive compounds.
  • Investigation of biosynthetic pathways and genetic mechanisms, including horizontal gene transfer.

Main Results:

  • Psychoactive compounds are present in multiple fungal phyla and genera with varied ecological roles.
  • Enzymes responsible for biosynthesis are encoded in metabolic gene clusters.
  • Horizontal gene transfer contributes to the patchy distribution of these compounds across fungal species.

Conclusions:

  • The study highlights the widespread nature and ecological significance of psychedelic compounds in fungi.
  • Understanding the biosynthesis and evolution of these substances is crucial for future research.
  • The re-emerging science of fungal psychedelics offers novel avenues for scientific and societal advancement.