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Retinal and Choroidal Thickness Changes in Populations with Helicobacter pylori Infection by Swept-Source Optical Coherence Tomography
Published on: November 1, 2024
179
Helicobacter Pylori Infection as an Independent Risk Factor for Kidney Stone Formation in China: A Cross-Sectional
Rui Gong1, Yan Ling1, Shi Wang2
1Health Management Center Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People's Republic of China.
Infection and Drug Resistance
|June 11, 2025
Summary
Helicobacter pylori (Hp) infection is an independent risk factor for kidney stone development. This study found a higher prevalence of kidney stones in Hp-positive individuals in China.
Area of Science:
- Nephrology
- Gastroenterology
- Epidemiology
Background:
- Helicobacter pylori (Hp) infection is prevalent globally and linked to various systemic effects.
- Kidney stone formation is a significant health concern with multifactorial causes.
- The association between Hp infection and kidney stones requires further investigation.
Purpose of the Study:
- To investigate the relationship between Helicobacter pylori infection and kidney stone formation.
- To determine if Hp infection is an independent risk factor for kidney stones in a Chinese population.
Main Methods:
- Cross-sectional study involving 76,749 participants (48,294 Hp-negative, 28,455 Hp-positive).
- Hp infection diagnosed via 13C urea breath test (13C-UBT).
- Kidney stones identified using urinary Doppler ultrasonography; statistical analyses included regression models.
Main Results:
- Hp-positive individuals exhibited a significantly higher prevalence of kidney stones compared to Hp-negative individuals.
- Hp infection was identified as an independent risk factor for kidney stones (OR: 1.275, P < 0.001) after adjusting for confounders.
- Hp-negative individuals had higher blood urea nitrogen, serum creatinine, and uric acid levels, and lower urine pH.
Conclusions:
- Helicobacter pylori infection is an independent risk factor for kidney stone development.
- Findings suggest a potential link between upper gastrointestinal infection and urinary system pathology.
- Further research is warranted to elucidate the mechanisms underlying this association.
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