Depression and Its Determinants Among Patients With Sickle Cell Disease: A Cross-Sectional Study

Area of Science:

• Medical Research
• Hematology
• Psychiatry

Background:

• Depression is a significant concern in sickle cell disease (SCD) patients, often overlooked and inadequately treated.
• Underdiagnosis and undertreatment of depression in SCD can lead to adverse health outcomes.

Purpose of the Study:

• To determine the prevalence of depression among individuals with SCD.
• To identify sociodemographic, clinical, and psychological factors associated with depression in SCD patients.

Main Methods:

• A cross-sectional study was conducted in Nepal involving 358 SCD patients aged over 13.
• Depression was assessed using the Beck Depression Inventory (BDI).
• Logistic regression analysis was employed to identify determinants of depression.

Main Results:

• The prevalence of depression was 36.31% in the studied SCD population.
• Age (40-49 years), SCD complications, and genetic counseling were associated with increased depression risk.
• Lower middle-class status, pain crises, moderate self-esteem, and discrimination were linked to decreased depression likelihood.

Conclusions:

• Depression is highly prevalent in patients with SCD.
• Sociodemographic, clinical, and psychological factors significantly influence depression in SCD.
• There is an urgent need for early screening and intervention for depression in SCD patients.